Michio Komai Selected Research

Nitric Oxide (Nitrogen Monoxide)

12/2011	Novel effect of adenosine 5'-monophosphate on ameliorating hypertension and the metabolism of lipids and glucose in stroke-prone spontaneously hypertensive rats.
3/2009	Adenosine, an identified active component from the Driselase-treated fraction of rice bran, is effective at improving metabolic syndrome in stroke-prone spontaneously hypertensive rats.
1/2007	The Driselase-treated fraction of rice bran is a more effective dietary factor to improve hypertension, glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats compared to ferulic acid.

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Michio Komai Research Topics

Disease

12	Inflammation (Inflammations) 09/2022 - 04/2006
11	Body Weight (Weight, Body) 02/2024 - 05/2008
11	Stroke (Strokes) 11/2018 - 03/2006
9	Hypertension (High Blood Pressure) 02/2024 - 01/2007
7	Neoplasms (Cancer) 10/2020 - 11/2008
5	Insulin Resistance 08/2020 - 04/2012
4	Hypogonadism (Hypergonadotropic Hypogonadism) 11/2022 - 09/2011
4	Colitis 01/2022 - 01/2017
4	Osteoporosis 07/2021 - 12/2005
3	Leukemia 04/2017 - 11/2007
2	Liver Diseases (Liver Disease) 07/2021 - 12/2012
2	Hyperglycemia 04/2012 - 12/2011
2	Vitamin K Deficiency 07/2011 - 10/2006
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 07/2010 - 03/2009
1	Neuroinflammatory Diseases 01/2022
1	Pruritus (Itching) 07/2021
1	Cholestasis 07/2021
1	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 07/2021
1	Carcinoma (Carcinomatosis) 05/2021
1	Diabetes Mellitus 08/2020
1	Diabetes Complications 08/2020
1	Type 2 Diabetes Mellitus (MODY) 08/2020
1	Muscular Atrophy (Muscle Atrophy) 08/2020
1	Genomic Instability 01/2020
1	Insulinoma 04/2019
1	Obesity 11/2018
1	Body Weight Changes 07/2017
1	Atherosclerosis 04/2017
1	Ulcerative Colitis 01/2017
1	Glucose Intolerance 11/2016

Drug/Important Bio-Agent (IBA)

10	Glucose (Dextrose)FDA LinkGeneric 04/2019 - 03/2006
8	Testosterone (Sustanon)FDA Link 11/2022 - 10/2006
6	LipopolysaccharidesIBA 09/2022 - 04/2006
6	menatetrenoneIBA 09/2021 - 12/2005
6	Vitamin K FDA Link 07/2021 - 04/2006
5	Biotin (Vitamin H)FDA Link 11/2022 - 09/2004
5	Messenger RNA (mRNA)IBA 01/2022 - 11/2008
5	LipidsIBA 12/2011 - 03/2006
4	LigandsIBA 07/2021 - 11/2007
4	Adenosine (Adenocard)FDA LinkGeneric 11/2018 - 03/2009
4	Triglycerides (Triacylglycerol)IBA 01/2015 - 03/2009
3	CytokinesIBA 01/2022 - 07/2017
3	geranylgeraniolIBA 09/2021 - 04/2013
3	Vitamin K 2 (Vitamin K2)IBA 09/2021 - 12/2005
3	sodium sulfate (sodium bisulfate)FDA LinkGeneric 05/2021 - 01/2017
3	Dextrans (Dextran)FDA Link 05/2021 - 01/2017
3	Insulin (Novolin)FDA Link 11/2016 - 03/2009
3	8-Hydroxy-2'-DeoxyguanosineIBA 01/2015 - 01/2007
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2011 - 01/2007
2	tryptamineIBA 09/2022 - 07/2017
2	ChemokinesIBA 01/2022 - 07/2017
2	Interleukin-6 (Interleukin 6)IBA 01/2022 - 01/2017
2	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 10/2020 - 01/2016
2	Progesterone FDA LinkGeneric 10/2020 - 01/2016
2	Adenosine Monophosphate (AMP)IBA 11/2018 - 12/2011
2	AntioxidantsIBA 04/2017 - 12/2005
2	5-hydroxy-3,7,3',4'-tetramethoxyflavoneIBA 04/2017 - 01/2014
2	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2017 - 12/2005
2	Ethanol (Ethyl Alcohol)IBA 04/2017 - 12/2012
2	Tryptophan (L-Tryptophan)FDA Link 01/2017 - 06/2011
2	EnzymesIBA 11/2016 - 09/2011
2	AdiponectinIBA 12/2011 - 03/2009
2	LeptinIBA 09/2011 - 03/2009
2	Antihypertensive Agents (Antihypertensives)IBA 07/2010 - 04/2008
2	driselaseIBA 03/2009 - 01/2007
2	Vitamin E FDA LinkGeneric 11/2008 - 04/2002
2	ferulic acid (sodium ferulate)IBA 04/2008 - 01/2007
1	Peptides (Polypeptides)IBA 02/2024
1	Luteinizing Hormone (Lutropin)FDA LinkGeneric 11/2022
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2022
1	Advanced Glycation End ProductsIBA 01/2022
1	NF-kappa B (NF-kB)IBA 09/2021
1	Cholecalciferol (Vitamin D3)FDA Link 07/2021
1	Rifampin (Rifampicin)FDA LinkGeneric 07/2021
1	SulfoxidesIBA 10/2020
1	Hormones (Hormone)IBA 10/2020
1	Cysteine (L-Cysteine)FDA Link 10/2020
1	SteroidsIBA 10/2020
1	Streptozocin (Streptozotocin)FDA Link 08/2020
1	PolyphenolsIBA 01/2020
1	ResveratrolIBA 01/2020
1	VitaminsIBA 07/2018
1	MucinsIBA 07/2017
1	Peroxidase (Myeloperoxidase)IBA 07/2017
1	Volatile Fatty AcidsIBA 07/2017
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2017
1	Phenylthiourea (Phenylthiocarbamide)IBA 01/2017
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2017
1	Amino Acids FDA Link 01/2017
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2017
1	Superoxide DismutaseIBA 01/2015
1	CatalaseIBA 01/2015
1	5,7-dimethoxyflavoneIBA 01/2014
1	AntigensIBA 01/2014
1	Immunoglobulin E (IgE)IBA 01/2014
1	apigenin dimethyletherIBA 01/2014

Therapy/Procedure

6	Oral Administration 02/2024 - 04/2008
2	Therapeutics 11/2022 - 03/2021
1	Ligation 07/2021
1	Glycemic Control 08/2020